Krystal Biotech, Inc.

Names of Reporting Persons

Frazier Life Sciences IX, L.P.

Check the Appropriate Box if a Member of a Group (see instructions)

(a) ☐ (b) ☒

SEC USE ONLY

Citizenship or Place of Organization

Delaware

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SC 13G/A

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No. 3)*

Krystal Biotech, Inc.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

501147 102

(CUSIP Number)

December 31, 2020

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☒ Rule 13d-1(c)

☐ Rule 13d-1(d)

*	The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 501147 102

(1)

Consists of 895,000 shares of Common Stock held directly by Frazier Life Sciences IX, L.P. FHMLS IX, L.P. is the general partner of Frazier Life Sciences IX, L.P. and FHMLS IX, L.L.C. is the general partner of FHMLS IX, L.P. Patrick Heron and James Topper are the members of FHMLS IX, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences IX, L.P.

(2)	Based on 19,706,870 shares of Common Stock that were outstanding as of September 30, 2020 as set forth in the Issuer’s final prospectus filed with the SEC pursuant to Rule 424(b)(5) on December 31, 2020.

CUSIP No. 501147 102

(1)

(2)	Based on 19,706,870 shares of Common Stock that were outstanding as of September 30, 2020 as set forth in the Issuer’s final prospectus filed with the SEC pursuant to Rule 424(b)(5) on December 31, 2020.

CUSIP No. 501147 102

(1)

(2)	Based on 19,706,870 shares of Common Stock that were outstanding as of September 30, 2020 as set forth in the Issuer’s final prospectus filed with the SEC pursuant to Rule 424(b)(5) on December 31, 2020.

CUSIP No. 501147 102

(1)

(2)	Based on 19,706,870 shares of Common Stock that were outstanding as of September 30, 2020 as set forth in the Issuer’s final prospectus filed with the SEC pursuant to Rule 424(b)(5) on December 31, 2020.

CUSIP No. 501147 102

(1)

(2)	Based on 19,706,870 shares of Common Stock that were outstanding as of September 30, 2020 as set forth in the Issuer’s final prospectus filed with the SEC pursuant to Rule 424(b)(5) on December 31, 2020.


Item 1(a).	Name of Issuer: Krystal Biotech, Inc.

Item 1(b).	Address of Issuer’s Principal Executive Offices: 2100 Wharton Street, Suite 701, Pittsburgh, Pennsylvania 15203

Item 2(a).	Name of Person Filing: The entities and persons filing this statement (collectively, the “Reporting Persons”) are: Frazier Life Sciences IX, L.P. (“FLS IX”) FHMLS IX, L.P. FHMLS IX, L.L.C. James Topper (“Topper”) Patrick Heron (“Heron” and together with Topper, the “Members”)

Item 2(b).	Address of Principal Business Office or, if none, Residence: The address and principal business office of the Reporting Persons is: c/o Frazier Healthcare Partners 601 Union Street, Suite 3200 Seattle, Washington 98101

Item 2(c).	Citizenship:

	Entities:	FLS IX FHMLS IX, L.P. FHMLS IX, L.L.C.	- Delaware, U.S.A. - Delaware, U.S.A. - Delaware, U.S.A.

	Individuals:	Topper Heron	- United States Citizen - United States Citizen

Item 2(d).	Title of Class of Securities: Common Stock

Item 2(e).	CUSIP Number: 501147 102

Item 3.	If this statement is filed pursuant to §§240.13d-1(b), or 240.13d-2(b) or (c), check whether the person filing is a:

(a)	☐ Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o);

(b)	☐ Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

(c)	☐ Insurance company as defined in section 3(a)19) of the Act (15 U.S.C. 78c);

(d)	☐ Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);

(e)	☐ An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);

(f)	☐ An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);

(g)	☐ A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);

(h)	☐ A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i)	☐ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)	☐ A non-U.S. institution in accordance with §240.13d–1(b)(1)(ii)(J);

(k)	☐ Group, in accordance with §240.13d–1(b)(1)(ii)(K).

	If filing as a non-U.S. institution in accordance with §240.13d–1(b)(1)(ii)(J), please specify the type of institution:


	Item 4.			Ownership

	Provide the following information regarding the aggregate number and percentage of the class of securities of the Issuer identified in Item 1.

	(a)			AmountBeneficially Owned: See Row 9 of cover page for each Reporting Person.

	(b)			Percentof Class: See Row 11 of cover page for each Reporting Person

	(c)			Numberof shares as to which the person has:

				(i) Sole power to vote or to direct the vote: See Row 5 of cover page for each Reporting Person. (ii) Shared power to vote or to direct the vote: See Row 6 of cover page for each Reporting Person. (iii) Sole power to dispose or to direct the disposition of: See Row 7 of cover page for each Reporting Person. (iv) Shared power to dispose or to direct the disposition of: See Row 8 of cover page for each Reporting Person.

	Item 5.			Ownership of 5 Percent or Less of a Class

	If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following ☒.

	Item 6.			Ownership of More than 5 Percent on Behalf of Another Person

	Not applicable.

	Item 7.			Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

	Not applicable.

	Item 8.			Identification and Classification of Members of the Group

	Not applicable.

	Item 9.			Notice of Dissolution of a Group

	Not applicable.

	Item 10.			Certification

	Not applicable.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.


Date: February 4, 2021	FRAZIER LIFE SCIENCES IX, L.P. By FHMLS IX, L.P., its general partner By FHMLS IX, L.L.C., its general partner

	By:	/s/ Steve R. Bailey
		Steve R. Bailey, Chief Financial Officer

Date: February 4, 2021	FHMLS IX, L.P. By FHMLS IX, L.L.C., its general partner

	By:	/s/ Steve R. Bailey
		Steve R. Bailey, Chief Financial Officer

Date: February 4, 2021	FHMLS IX, L.L.C.

	By:	/s/ Steve R. Bailey
		Steve R. Bailey, Chief Financial Officer

Date: February 4, 2021	By:	*
		James Topper

Date: February 4, 2021	By:	*
		Patrick Heron


Date: February 4, 2021	*By:	/s/ Steve R. Bailey
		Steve R. Bailey, as Attorney-in-Fact

This Schedule 13G was executed by Steve R. Bailey on behalf of the individuals listed above pursuant to a Power of Attorney, a copy of which was filed with the SEC on July 31, 2017.